By Wojciech Gorczyca
This vast reference protecting neoplastic hematopathology contains over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and typically affected extranodal organs, with particular emphasis at the differential analysis. It discusses simple medical, prognostic, morphologic and phenotypic info, with quite a few tables summarizing the phenotypic profiles of the most typical hematologic tumors. an immense characteristic of this e-book is an method of hematologic tumors in response to the WHO category, with proper examples and emphasis at the most dear morphologic and immunophenotypic positive factors utilized in diagnosis.It should be a useful reference for all practicing hematologists, oncologists and pathologists.
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Additional info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
31 present an algorithmic approach to the possible diagnosis of lymphoma, CML, plasma cell myeloma and anemia/MDS, respectively. 12 presents the current WHO classification of the hematolymphoid tumors72–87. 12 WHO classification of tumors of hematopoietic and lymphoid tissues Mature B-cell neoplasms Chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) B-cell prolymphocytic leukemia (B-PLL) Lymphoplasmacytic lymphoma Marginal zone B-cell lymphoma (MZL) Splenic marginal zone lymphoma Nodal marginal zone lymphoma Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Hairy cell leukemia Plasma cell myeloma/plasmacytoma Follicular lymphoma (FL) Mantle cell lymphoma (MCL) Diffuse large B-cell lymphoma (DLBCL) Mediastinal (thymic) large B-cell lymphoma Intravascular large B-cell lymphoma Primary effusion lymphoma Introduction 53 Burkitt lymphoma/leukemia B-cell proliferations of uncertain malignant potential Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder, polymorphic Mature T-cell and NK-cell neoplasms T-cell prolymphocytic leukemia (T-PLL) T-cell large granular lymphocytic leukemia (T-LGL leukemia) Aggressive NK-cell leukemia Adult T-cell leukemia/lymphoma Extranodal NK/T-cell lymphoma, nasal type Enteropathy-type T-cell lymphoma Hepatosplenic T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Mycosis fungoides/Sezary syndrome (MF/SS) Primary cutaneous anaplastic large cell lymphoma Peripheral T-cell lymphoma, unspecified Angioimmunoblastic T-cell lymphoma (AILD lymphoma) Anaplastic large cell lymphoma (ALCL) T-cell proliferation of uncertain malignant potential Lymphomatoid papulosis Hodgkin lymphoma Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) Classical Hodgkin lymphoma (HL) Nodular sclerosis Hodgkin lymphoma Lymphocyte-rich classical Hodgkin lymphoma Mixed cellularity Hodgkin lymphoma Lymphocyte-depleted Hodgkin lymphoma Chronic myeloproliferative diseases Chronic myelogenous leukemia (CML) Chronic neutrophilic leukemia Chronic eosinophilic leukemia/hypereosinophilic syndrome Polycythemia vera (PV) Chronic idiopathic myelofibrosis (CIMF) Essential thrombocythemia (ET) Chronic myeloproliferative disease, unclassifiable Myelodysplastic/myeloproliferative diseases Chronic myelomonocytic leukemia (CMML) Atypical chronic myeloid leukemia Juvenile myelomonocytic leukemia Myelodysplastic/myeloproliferative diseases, unclassifiable Myelodysplastic syndromes Refractory anemia (RA) Refractory anemia with ringed sideroblasts (RARS) Refractory cytopenia with multilineage dysplasia (RCMD) Refractory anemia with excess blasts (RAEB) Atlas of differential diagnosis in neoplastic hematopathology 54 Myelodysplastic syndrome associated with isolated del(5q) Myelodysplastic syndrome, unclassifiable Acute myeloid leukemia (AML) AML with t(8;21), (AML1/ETO) AML with inv(16)(p13;q22) or t(16;16)(p13;q22) (acute myelomonocytic leukemia with eosinophilia; AML-M4Eo) Acute promyelocytic leukemia [AML with t(15;17)(q22;q12)], APL (AML-M3) Acute myeloid leukemia with multilineage dysplasia With prior myelodysplastic syndrome Without prior myelodysplastic syndrome Acute myeloid leukemia and myelodysplastic syndrome, therapy-related Acute myeloid leukemia, minimally differentiated (AML-M0) Acute myeloid leukemia without maturation (AML-M1) Acute myeloid leukemia with maturation (AML-M2) Acute myelomonocytic leukemia (AML-M4) Acute monoblastic leukemia (AML-M5) Acute erythroid leukemia (AML-M6) Acute megakaryoblastic leukemia (AML-M7) Acute basophilic leukemia Acute panmyelosis with myelofibrosis Myeloid sarcoma Acute leukemia of ambiguous lineage Precursor neoplasms Precursor B-cell neoplasms Precursor B lymphoblastic leukemia/lymphoma (B-ALL/LBL) Precursor T-neoplasms Precursor T lymphoblastic leukemia/lymphoma (T-ALL/LBL) Blastic NK-cell leukemia/lymphoma (DC2 leukemia) Histiocytic and dendritic-cell neoplasms Histiocytic sarcoma Langerhans cell histiocytosis/Langerhans cell sarcoma Interdigitating dendritic cell sarcoma Follicular dendritic cell sarcoma Mastocytosis Cutaneous mastocytosis Indolent systemic mastocytosis Systemic mastocytosis with associated clonal hematological disease Aggressive systemic mastocytosis Mast cell leukemia Mast cell sarcoma CHAPTER 2 Mature B-cell neoplasms Mature B-cell neoplasms, the most common type of malignant lymphoma, are a clonal proliferation of B-cells.
Upper panels represent a benign lymph node. Note moderate expression of all four pan-T antigens (arrow). Lower panels represent an example of T-cell lymphoma with aberrant expression of CD2 (brighter than normal T-cells marked with *), loss of CD5 and CD7, and increased forward scatter (arrow). 18 T-PLL (A, bone marrow staining for CD3; B, molecular test Atlas of differential diagnosis in neoplastic hematopathology 34 with clonal peak (arrow); C–G, flow cytometry). Flow cytometry immunophenotyping shows no loss of pan-T antigen expression (D–G).
2 shows cytologic features of B-SLL. Lymphocytes are small and round with scanty cytoplasm, dense and clumped chromatin and round nuclei without prominent nucleoli or irregular nuclear borders. 3). 4) may have cytomorphologic overlap with lymphoplasmacytic lymphoma. As in lymphoplasmacytic lymphoma, there is a mixed population of clonal B-cells and clonal plasma cells, but B-SLL differs by the phenotype.
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