By Reinhard H. H. Neubert, Hans-Hermann Ruttinger

ISBN-10: 0824709519

ISBN-13: 9780824709518

The authors supply suggestions to discover and represent interactions among medications, drug autos, and organic membranes to facilitate advancements in managed drug supply and concentrating on. The ebook comprises present purposes and strategies to spot binding constants among medicinal drugs, organic buildings, proteins, nucleic acids, and plasmids, elevate drug bioavailability, increase the permeability, solubility, energy, and serve as of drug formulations, study protein-protein exchanges and reactions, and calculate pKa values.

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Extra resources for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics

Example text

Theory and Method 1. Theory For a monobasic weak acid, HA, the thermodymanic dissociation constant (K tha ) is defined as follows: K ath = ␥AϪ {Hϩ}[AϪ] ␥AϪ ϫ = KЈa ␥HA [HA] ␥HA (1) where ␥ is an activity coefficient and {Hϩ} is the activity of a proton.

Capillary Gel Electrophoresis Separation with capillary gel electrophoresis is based on the mechanism of size exclusion. Therefore, GCE is directly comparable to traditional slab or tube gel electrophoresis, since the separation mechanisms are identical. In CGE the capillary is filled with a gel containing cross-linked or linear polymers. The gel thereby acts as molecular sieve. Traditionally, crosslinked polyacrylamides and agarose have been utilized in the slab and tube format. Polyacrylamides when cross-linked have smaller pore sizes and are used for protein separations.

Trends Anal. Chem. 8 (1989), 129. C. Rentel, P. Gfro¨rer, E. Bayer. Electrophoresis 20 (1999), 2329. I. Bjornsdottir, J. H. Hansen. Electrophoresis 19 (1998), 2179. J. T. Hansen. J. Pharm. Biomed. Anal. 15 (1997), 1077. T. Okada. J. Chromatogr. A 771 (1997), 275. © 2003 by Marcel Dekker, Inc. 2 Theory of Affinity Electrophoresis Hans-Hermann Ru¨ttinger Martin-Luther-University Halle-Wittenberg, Halle, Germany I. INTRODUCTION More or less specific noncovalent molecular interactions are ubiquitous in biological systems.

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