By Max Born, H. S. Green
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Extra info for A General Kinetic Theory of Liquids, Max Born and Green
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Ever since 1925, when Raymond Dart’s report of the first Australopithecus skull in southern Africa upended Victorian views of human origins, there has been debate over whether our species arose only once and spread throughout the world, replacing all extant species of Homo, or whether our ancestors interbred with the other populations and subspecies. The most extreme version of the ‘candelabra’ model of human origins — according to which human species arose multiple times independently of our Homo ergaster ancestors — has been largely discounted.
Because of the vast number of conformations that can potentially be adopted by flexible proteins, accurate identification of these ensembles presents an ill-defined ‘inverse problem’ — how can the ensembles be identified from acquired data? The solution requires the development of robust statistical approaches to determine the probability that any particular multiconformational equilibrium will exist9. A true statistical mechanical description of an ensemble also requires a quantitative assessment of the weighting of each conformation in the Boltzmann probability distribution of conformations.
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